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Week 10. Senior Travel. 89 item. Week 10. Short-Sleeve Fruit Salad. 84 item. Week 10. The Perfect Gift for Everyone on Your List!. 88 item. Week 10. Five-K Shopping. 84 item. Week 10. Multipartite with Peach-Ginger Sauce. 8 item. This Week’s Top 10. Includes a Few Surprises, but Mostly Cool Foods and Beverages. 8 item. This Week’s Top 10. 14 item. Week 10. Croc’s Outdoor Classic Menu. 9 item. Week 10. My List. 4 item. Week 10. Cooking Season. 5 item. Week 10. Day 2. 27 item. This Week’s Top 10. Includes a Few Surprises, but Mostly Cool Foods and Beverages. 8 item. 3 item. Week 10. Great Baked Goods. 10 item. Week 10. Day 1. 17 item.Mechanisms of action of a new 3,5-diisopropylidene-1,5-dihydro-2H-pyrrolo[3,4-b]pyrazine 2,4-dione which blocks pacemaker activity of the heart. We investigated the mechanisms of action of 3,5-diisopropylidene-1,5-dihydro-2H-pyrrolo[3,4-b]pyrazine 2,4-dione (DPDP) which block pacemaker activity in hearts from various species, and also in the isolated rabbit sinoatrial node, atrioventricular node, and Purkinje fibers. DPDP (1.0-10.0 microM) hyperpolarized the resting membrane potentials of pacemaker and sinoatrial cells, depressed the slow delayed rectifier K current, and also depressed the A-type K current. These effects were reversible. DPDP (1.0-10.0 microM) also hyperpolarized the resting membrane potentials of atrioventricular and Purkinje fibers. It depressed the slow inward and slow outward current and also the A-type K current. All these effects were reversible. DPDP (0.1-10.0 microM) also hyperpolarized the resting membrane potentials of atrioventricular and Purkinje fibers and depressed the slow inward current and the A-type K current.

 

 


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